BDBM50183959 4-(1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-ylamino)-6-(difluoromethoxy)-1-methylquinolin-2(1H)-one::CHEMBL206030

SMILES Cn1c2ccc(OC(F)F)cc2c(NC2CCN(Cc3ccc4OCOc4c3)CC2)cc1=O

InChI Key InChIKey=LZVOCVBJCLTFOL-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50183959   

TargetMelanin-concentrating hormone receptor 1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50183959(4-(1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-y...)
Affinity DataIC50: 5nMAssay Description:Displacement of [125I]MCH from MCHr1 expressed in IMR32 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50183959(4-(1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-y...)
Affinity DataIC50: 34nMAssay Description:Inhibition of MCH-mediated calcium release in whole IMR32 cells by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50183959(4-(1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-y...)
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to hERG stably transfected in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed