BDBM50185805 3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl)-5-fluoro-1H-indole::CHEMBL211722

SMILES Fc1ccc2[nH]cc(C3CCN(CC3)C3Cc4cccc5cccc3c45)c2c1

InChI Key InChIKey=KSNSVNQHQZZXOD-UHFFFAOYSA-N

Data  4 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50185805   

TargetNociceptin receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50185805(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl...)
Affinity DataKi:  18nMAssay Description:Displacement of [125I]Tyr14-nociceptin from ORL1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50185805(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl...)
Affinity DataKi:  500nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50185805(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl...)
Affinity DataKi:  1.89E+3nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50185805(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl...)
Affinity DataKi: >5.00E+3nMAssay Description:Displacement of [3H]DDPDE from delta opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50185805(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl...)
Affinity DataEC50:  2.72E+4nMAssay Description:Agonist activity at ORL1 receptor expressed in HEK293 cells by calciun flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed