BDBM50187345 (5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)-methanone::CHEMBL207858

SMILES Cc1cccc2[nH]c(cc12)C(=O)c1cc2cc(O)ccc2[nH]1

InChI Key InChIKey=QNNCAUNEIPNZAQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50187345   

TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187345((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...)
Affinity DataIC50:  458nMAssay Description:Inhibition of human PDGFR betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187345((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...)
Affinity DataIC50:  500nMAssay Description:Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing wildtype KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187345((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...)
Affinity DataIC50:  60nMAssay Description:Inhibition of endogenous FLT3 in EOL1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187345((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...)
Affinity DataIC50:  960nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187345((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187345((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...)
Affinity DataIC50:  500nMAssay Description:Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing KIT V558D mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed