BDBM50188749 1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)methyl)-3-(3-(trifluoromethyl)phenyl)urea::1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)methyl)-3-(3-(trifluoromethyl)phenyl)urea::CHEMBL213910

SMILES CN1CCN(Cc2ccc3c(c2)-c2n[nH]c(-c4ccc(CN(C)C(=O)Nc5cccc(C(F)(F)F)c5)s4)c2C3)CC1

InChI Key InChIKey=UKSRSPVTFVLKRY-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50188749   

TargetVascular endothelial growth factor receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50188749BDBM50188749(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Affinity DataIC50: 11nMAssay Description:Inhibition of KDR at 1 mM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50188749BDBM50188749(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Affinity DataIC50: 11nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50188749BDBM50188749(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Affinity DataIC50: 14nMAssay Description:Inhibition of FLT1 at 1 mM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50188749BDBM50188749(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Affinity DataIC50: 14nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50188749BDBM50188749(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Affinity DataIC50: 18nMAssay Description:Inhibition of cKit at 1 mM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50188749BDBM50188749(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Affinity DataIC50: 18nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50188749BDBM50188749(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Affinity DataIC50: 195nMAssay Description:Inhibition of KDR phosphorylation in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Schering-Plough

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50188749BDBM50188749(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Affinity DataIC50: 259nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Schering-Plough

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50188749BDBM50188749(1-methyl-1-((5-(7-((4-methylpiperazin-1-yl)methyl)...)
Affinity DataIC50: 259nMAssay Description:Inhibition of Tie2 at 1 mM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed