BDBM50189310 4,4''-(1,4-Phenylenebis(Methylene))Bis(Oxy)Dibenzimidamide::CHEMBL365916

SMILES NC(=N)c1ccc(OCc2ccc(COc3ccc(cc3)C(N)=N)cc2)cc1

InChI Key InChIKey=CMQUKOACSUWXOS-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50189310   

TargetTrypsin(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50189310(CHEMBL365916 | 4,4''-(1,4-Phenylenebis(Methylene))...)
Affinity DataKi:  316nMAssay Description:Inhibition of human trypsin using Boc-Gln-Ala-Arg-AMC as substrate after 20 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2017
Entry Details Article
PubMed
TargetCoagulation factor X(Bovine)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50189310(CHEMBL365916 | 4,4''-(1,4-Phenylenebis(Methylene))...)
Affinity DataKi:  327nMAssay Description:Inhibition of bovine factor 10a using Boc-Ile-Glu-Gly-Arg-AMC as substrate after 20 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2017
Entry Details Article
PubMed
TargetSuppressor of tumorigenicity 14 protein(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50189310(CHEMBL365916 | 4,4''-(1,4-Phenylenebis(Methylene))...)
Affinity DataKi:  816nMAssay Description:Inhibition of human matriptase using Boc-Gln-Ala-Arg-AMC as substrate after 20 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2017
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50189310(CHEMBL365916 | 4,4''-(1,4-Phenylenebis(Methylene))...)
Affinity DataKi:  1.16E+3nMAssay Description:Inhibition of human thrombin using Cbz-Gly-Gly-Arg-AMC as substrate after 20 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2017
Entry Details Article
PubMed
TargetProthrombin(Bovine)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50189310(CHEMBL365916 | 4,4''-(1,4-Phenylenebis(Methylene))...)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of bovine thrombin using BANA/BPVANA as substrate after 15 to 40 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2017
Entry Details Article
PubMed
TargetTransmembrane protease serine 6(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50189310(CHEMBL365916 | 4,4''-(1,4-Phenylenebis(Methylene))...)
Affinity DataKi:  5.70E+3nMAssay Description:Inhibition of human matriptase-2 transfected in HEK cells using Boc-Gln-Ala-Arg-AMC as substrate after 20 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2017
Entry Details Article
PubMed