BDBM50190543 1-((2R,4S,5R)-4-hydroxy-5-((tritylamino)methyl)-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione::1-((2R,4S,5R)-4-hydroxy-5-((tritylamino)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione::CHEMBL377582

SMILES O[C@H]1C[C@@H](O[C@@H]1CNC(c1ccccc1)(c1ccccc1)c1ccccc1)n1ccc(=O)[nH]c1=O

InChI Key InChIKey=TUZNCXRMWDUVNX-BFLUCZKCSA-N

Data  6 KI

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50190543   

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase(Plasmodium falciparum (isolate 3D7))
University of Wales Cardiff

Curated by ChEMBL
LigandPNGBDBM50190543(1-((2R,4S,5R)-4-hydroxy-5-((tritylamino)methyl)-te...)
Affinity DataKi:  200nMAssay Description:Inhibition of Plasmodium falciparum dUTPaseMore data for this Ligand-Target Pair
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase(Plasmodium falciparum (isolate 3D7))
University of Wales Cardiff

Curated by ChEMBL
LigandPNGBDBM50190543(1-((2R,4S,5R)-4-hydroxy-5-((tritylamino)methyl)-te...)
Affinity DataKi:  200nMAssay Description:Inhibition of Plasmodium falciparum dUTPaseMore data for this Ligand-Target Pair
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
University of Wales Cardiff

Curated by ChEMBL
LigandPNGBDBM50190543(1-((2R,4S,5R)-4-hydroxy-5-((tritylamino)methyl)-te...)
Affinity DataKi:  4.60E+4nMAssay Description:Inhibition of human dUTPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
University of Wales Cardiff

Curated by ChEMBL
LigandPNGBDBM50190543(1-((2R,4S,5R)-4-hydroxy-5-((tritylamino)methyl)-te...)
Affinity DataKi:  4.60E+4nMAssay Description:Inhibition of human dUTPase using dUTP as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
University of Wales Cardiff

Curated by ChEMBL
LigandPNGBDBM50190543(1-((2R,4S,5R)-4-hydroxy-5-((tritylamino)methyl)-te...)
Affinity DataKi:  4.60E+4nMAssay Description:Inhibition of recombinant human dUTPase expressed in Escherichia coli BL21 (DE3) using dUTP as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Human)
University of Wales Cardiff

Curated by ChEMBL
LigandPNGBDBM50190543(1-((2R,4S,5R)-4-hydroxy-5-((tritylamino)methyl)-te...)
Affinity DataKi:  4.60E+4nMAssay Description:Inhibition of human recombinant dUTPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed