BDBM50193536 N-cyclopropylmethyl-14beta-(2'-methylcinnamoylamino)-7,8-dihydronorcodeinone

SMILES COc1ccc2CC3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35NC(=O)\C=C\c1ccccc1C

InChI Key InChIKey=HKFWFMQRXDJWRR-UHFFFAOYSA-N

Data  3 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50193536   

TargetMu-type opioid receptor(Guinea pig)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50193536(N-cyclopropylmethyl-14beta-(2'-methylcinnamoylamin...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to MOR in guinea pig brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50193536(N-cyclopropylmethyl-14beta-(2'-methylcinnamoylamin...)
Affinity DataEC50:  1.80nMAssay Description:Stimulation of [35S]GTP-gamma-S binding to human recombinant KORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50193536(N-cyclopropylmethyl-14beta-(2'-methylcinnamoylamin...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity to KOR in guinea pig brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50193536(N-cyclopropylmethyl-14beta-(2'-methylcinnamoylamin...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to DOR in guinea pig brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50193536(N-cyclopropylmethyl-14beta-(2'-methylcinnamoylamin...)
Affinity DataEC50:  2.60nMAssay Description:Stimulation of [35S]GTPgammaS binding to human recombinant MORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50193536(N-cyclopropylmethyl-14beta-(2'-methylcinnamoylamin...)
Affinity DataEC50:  21nMAssay Description:Stimulation of [35S]GTP-gamma-S binding to human recombinant DORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed