BDBM50193807 CHEMBL3961771

SMILES COc1c(Nc2ncc(Cl)c(Nc3ccccc3N(C)S(C)(=O)=O)n2)ccc2CC(CCCc12)N1CCN(C)CC1

InChI Key InChIKey=ZTOIRWCKMDSZQZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50193807   

TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Teva Branded Pharmaceutical Products R & D

Curated by ChEMBL
LigandPNGBDBM50193807(CHEMBL3961771)
Affinity DataIC50:  40nMAssay Description:Inhibition of NPM-ALK phosphorylation in human SUP-M2 cells after 2 to 3 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Teva Branded Pharmaceutical Products R & D

Curated by ChEMBL
LigandPNGBDBM50193807(CHEMBL3961771)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human ALK expressed in baculovirus using recombinant GST PLC-gamma as substrate assessed as phosphorylation of the substrate after 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Teva Branded Pharmaceutical Products R & D

Curated by ChEMBL
LigandPNGBDBM50193807(CHEMBL3961771)
Affinity DataIC50:  1.76E+3nMAssay Description:Inhibition of recombinant human INSR expressed in baculovirus using ATP as substrate after 15 mins by TRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Teva Branded Pharmaceutical Products R & D

Curated by ChEMBL
LigandPNGBDBM50193807(CHEMBL3961771)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human FAK expressed in baculovirus after 30 mins using biotinyl-amino-hexanoyl-EQEDEPEGDYFEWLE-amide as substrate by TRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed