BDBM50194933 CHEMBL3956625

SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1c(F)cccc1Oc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O

InChI Key InChIKey=XDRHCUWKZRZSEP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50194933   

TargetSerine/threonine-protein kinase PLK1(Human)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50194933(CHEMBL3956625)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of 5CF-GPMQSpTPLNG-NH2 binding to myc-tagged human Plk1 PBD expressed in HEK-293T cells incubated for 1 hr by fluorescence polarization as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50194933(CHEMBL3956625)
Affinity DataIC50: 66nMAssay Description:Inhibition of Biotin-Ahx-PMQS(pT)PLN-NH2 binding to human full length N-terminal myc-tagged PLK1 expressed in HEK293T cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50194933(CHEMBL3956625)
Affinity DataIC50: 127nMAssay Description:Inhibition of Biotin-Ahx-PMQS(pT)PLN-NH2 binding to myc-tagged full-length human Plk1 expressed in HEK-293T cells incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK2(Human)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50194933(CHEMBL3956625)
Affinity DataIC50: 290nMAssay Description:Inhibition of 5CF-GPMQTSpTPKNG-NH2 binding to myc-tagged Plk2 (unknown origin) PBD expressed in HEK-293T cells incubated for 1 hr by fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50194933(CHEMBL3956625)
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of 5CF-PLATSpTPKNG-NH2 binding to myc-tagged Plk3 (unknown origin) PBD expressed in HEK-293T cells incubated for 1 hr by fluorescence pola...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2020
Entry Details Article
PubMed