BDBM50195670 CHEMBL216558::N-cyclopropylmethyl-14beta-[4'-(4''-chlorophenyl)-2'-butenamino]-7,8-dihydronormorphinone

SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35NC\C=C\Cc1ccc(Cl)cc1

InChI Key InChIKey=RTIXOOXRVMHTBL-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50195670   

TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50195670(N-cyclopropylmethyl-14beta-[4'-(4''-chlorophenyl)-...)
Affinity DataIC50: 1.20nMAssay Description:Activity at human recombinant mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50195670(N-cyclopropylmethyl-14beta-[4'-(4''-chlorophenyl)-...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50195670(N-cyclopropylmethyl-14beta-[4'-(4''-chlorophenyl)-...)
Affinity DataIC50: 3.40nMAssay Description:Activity at human recombinant delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50195670(N-cyclopropylmethyl-14beta-[4'-(4''-chlorophenyl)-...)
Affinity DataIC50: 3.5nMAssay Description:Activity at human recombinant kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50195670(N-cyclopropylmethyl-14beta-[4'-(4''-chlorophenyl)-...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [3H]U-69593 from human recombinant kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50195670(N-cyclopropylmethyl-14beta-[4'-(4''-chlorophenyl)-...)
Affinity DataKi:  6.70nMAssay Description:Displacement of [3H]Cl-DPDPE from human recombinant delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed