BDBM50196227 CHEMBL386064::S-(+)-2beta-carbomethoxy-3alpha-[bis(4-chlorophenyl)methoxy]tropane

SMILES COC(=O)[C@@H]1C2CCC(C[C@@H]1OC(c1ccc(Cl)cc1)c1ccc(Cl)cc1)N2C

InChI Key

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50196227   

TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50196227(S-(+)-2beta-carbomethoxy-3alpha-[bis(4-chloropheny...)
Affinity DataIC50: 2.46nMAssay Description:Inhibition of [3H]dopamine uptake at DAT in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50196227(S-(+)-2beta-carbomethoxy-3alpha-[bis(4-chloropheny...)
Affinity DataKi:  12.6nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50196227(S-(+)-2beta-carbomethoxy-3alpha-[bis(4-chloropheny...)
Affinity DataKi:  382nMAssay Description:Displacement of [3H]pirenzepine from M1 receptor in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50196227(S-(+)-2beta-carbomethoxy-3alpha-[bis(4-chloropheny...)
Affinity DataKi:  528nMAssay Description:Displacement of [3H]citalopram from SERT in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50196227(S-(+)-2beta-carbomethoxy-3alpha-[bis(4-chloropheny...)
Affinity DataKi:  2.15E+3nMAssay Description:Displacement of [3H]nisoxetine from NET in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed