BDBM50196528 CHEMBL3923120::US10167270, Example 00161::US10501435, Compound 9c

SMILES C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccnc1

InChI Key InChIKey=XXCCBJLQMRHXKM-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50196528   

TargetLysosomal acid glucosylceramidase(Human)
Northwestern University

US Patent
LigandPNGBDBM50196528(CHEMBL3923120 | US10167270, Example 00161 | US1050...)
Affinity DataIC50: 7nMAssay Description:The enzyme in GCase enzyme activity buffer (25 μL/well) was added to a 384-well black plate. The fluorescent probe 3 (25 nL/well, 50 nM final co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
Northwestern University

US Patent
LigandPNGBDBM50196528(CHEMBL3923120 | US10167270, Example 00161 | US1050...)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of wild type recombinant human lysosomal beta-glucocerebrosidase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
Northwestern University

US Patent
LigandPNGBDBM50196528(CHEMBL3923120 | US10167270, Example 00161 | US1050...)
Affinity DataIC50: 8.30nMpH: 5.9Assay Description:Inhibition of synthetic recombinant wild type GCase enzyme velaglucerase alfa (unknown origin) at pH 5.9 preincubated for 5 mins followed by addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2018
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
Northwestern University

US Patent
LigandPNGBDBM50196528(CHEMBL3923120 | US10167270, Example 00161 | US1050...)
Affinity DataIC50: 8.30nMAssay Description:The compounds in DMSO solution (0.5 μL/well) were transferred to a black 96-well plate (the final titration started from 100 μM, a 12 or 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
Northwestern University

US Patent
LigandPNGBDBM50196528(CHEMBL3923120 | US10167270, Example 00161 | US1050...)
Affinity DataIC50: 8.30nMAssay Description:The enzyme in GCase enzyme activity buffer (25 μL/well) was added to a 384-well black plate. The fluorescent probe 3 (25 nL/well, 50 nM final co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
Northwestern University

US Patent
LigandPNGBDBM50196528(CHEMBL3923120 | US10167270, Example 00161 | US1050...)
Affinity DataIC50: 8.30nMAssay Description:pH = 5.9.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
Northwestern University

US Patent
LigandPNGBDBM50196528(CHEMBL3923120 | US10167270, Example 00161 | US1050...)
Affinity DataIC50: 12.7nMAssay Description:pH = 7.0.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
Northwestern University

US Patent
LigandPNGBDBM50196528(CHEMBL3923120 | US10167270, Example 00161 | US1050...)
Affinity DataIC50: 12.7nMAssay Description:The compounds in DMSO solution (0.5 μL/well) were transferred to a black 96-well plate (the final titration started from 100 μM, a 12 or 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
Northwestern University

US Patent
LigandPNGBDBM50196528(CHEMBL3923120 | US10167270, Example 00161 | US1050...)
Affinity DataIC50: 13nMpH: 7.0Assay Description:Inhibition of synthetic recombinant wild type GCase enzyme velaglucerase alfa (unknown origin) at pH 7 preincubated for 5 mins followed by addition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2018
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
Northwestern University

US Patent
LigandPNGBDBM50196528(CHEMBL3923120 | US10167270, Example 00161 | US1050...)
Affinity DataIC50: 25.9nMAssay Description:The compounds in DMSO solution (0.5 μL/well) were transferred to a black 96-well plate (the final titration started from 100 μM, a 12 or 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
Northwestern University

US Patent
LigandPNGBDBM50196528(CHEMBL3923120 | US10167270, Example 00161 | US1050...)
Affinity DataIC50: 25.9nMAssay Description:pH = 5.0.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
Northwestern University

US Patent
LigandPNGBDBM50196528(CHEMBL3923120 | US10167270, Example 00161 | US1050...)
Affinity DataIC50: 26nMpH: 5.0Assay Description:Inhibition of synthetic recombinant wild type GCase enzyme velaglucerase alfa (unknown origin) at pH 5 preincubated for 5 mins followed by addition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2018
Entry Details Article
PubMed