BDBM50198115 CHEMBL438304::N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-(2-acetamido-1,3-thiazol-4-yl)-4-[(5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]butanamide

SMILES C[C@H]1CN(CCC(C(=O)NCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c2csc(NC(C)=O)n2)CCC11C=Cc2ccccc12

InChI Key InChIKey=KOQXGZHDIQDDAK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50198115   

TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50198115(N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-(2-ac...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of MCP1-stimulated chemotaxis in monocytes transfected with human CCR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50198115(N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-(2-ac...)
Affinity DataIC50: 3nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed