BDBM50198426 CHEMBL233047::N4-(2,4-dichlorobenzyl)-N2-(4-(diethylamino)pentyl)pyrimidine-2,4-diamine

SMILES CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1

InChI Key InChIKey=HILQSLVIBNFOMC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50198426   

TargetC-C chemokine receptor type 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50198426(N4-(2,4-dichlorobenzyl)-N2-(4-(diethylamino)pentyl...)
Affinity DataIC50: 280nMAssay Description:Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50198426(N4-(2,4-dichlorobenzyl)-N2-(4-(diethylamino)pentyl...)
Affinity DataIC50: 300nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50198426(N4-(2,4-dichlorobenzyl)-N2-(4-(diethylamino)pentyl...)
Affinity DataIC50: 800nMAssay Description:Antagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50198426(N4-(2,4-dichlorobenzyl)-N2-(4-(diethylamino)pentyl...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed