BDBM50198789 4-(7-(4-fluoro-2-methylphenyl)-6-methylbenzo[e][1,2,4]triazin-3-ylamino)-N-(2-(pyrrolidin-1-yl)ethyl)benzenesulfonamide::CHEMBL397691::US8481536, 460::US8481536, 601

SMILES Cc1cc(F)ccc1-c1cc2nnc(Nc3ccc(cc3)S(=O)(=O)NCCN3CCCC3)nc2cc1C

InChI Key InChIKey=JUGGLTJXSGBAFT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50198789   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198789(US8481536, 460 | CHEMBL397691 | US8481536, 601 | 4...)
Affinity DataIC50: 20nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198789(US8481536, 460 | CHEMBL397691 | US8481536, 601 | 4...)
Affinity DataIC50: 20.4nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Targegen

US Patent
LigandPNGBDBM50198789(US8481536, 460 | CHEMBL397691 | US8481536, 601 | 4...)
Affinity DataIC50: 73.7nMAssay Description:Pdgfrβ (0.16 ug/well, Panvera/Invitrogen) 500 nM ATP and the PTK2 peptide (700 uM) were combined with compound and reaction buffer as noted abov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent