BDBM50198791 7-(2,6-dimethylphenyl)-5-methyl-N-(2-(2-(pyrrolidin-1-yl)ethoxy)pyridin-4-yl)benzo[e][1,2,4]triazin-3-amine::CHEMBL437004::US8481536, 388::US8481536, 584

SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccnc(OCCN4CCCC4)c3)nnc2c1

InChI Key InChIKey=YHHHJKZCRBUOTD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50198791   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

US Patent
LigandPNGBDBM50198791(CHEMBL437004 | US8481536, 584 | US8481536, 388 | 7...)
Affinity DataIC50: 5.60nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

US Patent
LigandPNGBDBM50198791(CHEMBL437004 | US8481536, 584 | US8481536, 388 | 7...)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Targegen

US Patent
LigandPNGBDBM50198791(CHEMBL437004 | US8481536, 584 | US8481536, 388 | 7...)
Affinity DataIC50: 128nMT: 2°CAssay Description:EphB4 kinase activity was similarly measured, using the luciferase-based technique described above. 28.9 mU/well EphB4 (Upstate) was reacted with 1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent