BDBM50198795 7-(2,6-dimethylphenyl)-5-methyl-N-(3-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)benzo[e][1,2,4]triazin-3-amine::CHEMBL230615::US8481536, 379::US8481536, 580

SMILES CN1CCN(CCOc2cccc(Nc3nnc4cc(cc(C)c4n3)-c3c(C)cccc3C)c2)CC1

InChI Key InChIKey=LARRSIBKNUNYRQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50198795   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

US Patent
LigandPNGBDBM50198795(US8481536, 580 | US8481536, 379 | CHEMBL230615 | 7...)
Affinity DataIC50: 39.5nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

US Patent
LigandPNGBDBM50198795(US8481536, 580 | US8481536, 379 | CHEMBL230615 | 7...)
Affinity DataIC50: 40nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Targegen

US Patent
LigandPNGBDBM50198795(US8481536, 580 | US8481536, 379 | CHEMBL230615 | 7...)
Affinity DataIC50: 69.1nMAssay Description:Pdgfrβ (0.16 ug/well, Panvera/Invitrogen) 500 nM ATP and the PTK2 peptide (700 uM) were combined with compound and reaction buffer as noted abov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent