BDBM50198805 5-methyl-7-phenyl-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)benzo[e][1,2,4]triazin-3-amine::7-phenyl-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-::CHEMBL230685::US8481536, 524::US8481536, 615

SMILES Cc1cc(cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12)-c1ccccc1

InChI Key InChIKey=ZUMICAGHFTUJTI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50198805   

TargetTyrosine-protein kinase Yes(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198805(US8481536, 524 | US8481536, 615 | 7-phenyl-5-methy...)
Affinity DataIC50: 110nMAssay Description:Inhibition of YESMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198805(US8481536, 524 | US8481536, 615 | 7-phenyl-5-methy...)
Affinity DataIC50: 111nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198805(US8481536, 524 | US8481536, 615 | 7-phenyl-5-methy...)
Affinity DataIC50: 340nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198805(US8481536, 524 | US8481536, 615 | 7-phenyl-5-methy...)
Affinity DataIC50: 341nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198805(US8481536, 524 | US8481536, 615 | 7-phenyl-5-methy...)
Affinity DataIC50: 341nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent

TargetEphrin type-B receptor 4(Human)
Targegen

US Patent
LigandPNGBDBM50198805(US8481536, 524 | US8481536, 615 | 7-phenyl-5-methy...)
Affinity DataIC50: 391nMT: 2°CAssay Description:EphB4 kinase activity was similarly measured, using the luciferase-based technique described above. 28.9 mU/well EphB4 (Upstate) was reacted with 1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent

LigandPNGBDBM50198805(US8481536, 524 | US8481536, 615 | 7-phenyl-5-methy...)
Affinity DataIC50: 530nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed