BDBM50198813 7-(2-chlorophenyl)-5-methyl-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)benzo[e][1,2,4]triazin-3-amine::7-(2-chlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amine::CHEMBL268825::US8481536, 523::US8481536, 614

SMILES Cc1cc(cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12)-c1ccccc1Cl

InChI Key InChIKey=NYEBJLYZEHKODB-UHFFFAOYSA-N

Data  2 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50198813   

TargetTyrosine-protein kinase Yes(Human)
Targegen

US Patent
LigandPNGBDBM50198813(US8481536, 614 | US8481536, 523 | 7-(2-chloropheny...)
Affinity DataIC50: 21.7nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent

TargetTyrosine-protein kinase Yes(Human)
Targegen

US Patent
LigandPNGBDBM50198813(US8481536, 614 | US8481536, 523 | 7-(2-chloropheny...)
Affinity DataIC50: 22nMAssay Description:Inhibition of YESMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

US Patent
LigandPNGBDBM50198813(US8481536, 614 | US8481536, 523 | 7-(2-chloropheny...)
Affinity DataIC50: 34.8nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

US Patent
LigandPNGBDBM50198813(US8481536, 614 | US8481536, 523 | 7-(2-chloropheny...)
Affinity DataKi:  35nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

US Patent
LigandPNGBDBM50198813(US8481536, 614 | US8481536, 523 | 7-(2-chloropheny...)
Affinity DataIC50: 35nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

US Patent
LigandPNGBDBM50198813(US8481536, 614 | US8481536, 523 | 7-(2-chloropheny...)
Affinity DataIC50: 35nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198813(US8481536, 614 | US8481536, 523 | 7-(2-chloropheny...)
Affinity DataKi:  42nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Targegen

US Patent
LigandPNGBDBM50198813(US8481536, 614 | US8481536, 523 | 7-(2-chloropheny...)
Affinity DataIC50: 58nMT: 2°CAssay Description:EphB4 kinase activity was similarly measured, using the luciferase-based technique described above. 28.9 mU/well EphB4 (Upstate) was reacted with 1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent

LigandPNGBDBM50198813(US8481536, 614 | US8481536, 523 | 7-(2-chloropheny...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed