BDBM50198817 4-(7-(2,6-dimethylphenyl)-5-methylbenzo[e][1,2,4]triazin-3-ylamino)-N-(2-(pyrrolidin-1-yl)ethyl)benzenesulfonamide::CHEMBL231218::US8481536, 404::US8481536, 586

SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(cc3)S(=O)(=O)NCCN3CCCC3)nnc2c1

InChI Key InChIKey=DYHVAHJSHIYCLL-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50198817   

TargetTyrosine-protein kinase Yes(Human)
Targegen

US Patent
LigandPNGBDBM50198817(US8481536, 586 | US8481536, 404 | CHEMBL231218 | 4...)
Affinity DataIC50: 3.10nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198817(US8481536, 586 | US8481536, 404 | CHEMBL231218 | 4...)
Affinity DataIC50: 9nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50198817(US8481536, 586 | US8481536, 404 | CHEMBL231218 | 4...)
Affinity DataIC50: 9.10nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Targegen

US Patent
LigandPNGBDBM50198817(US8481536, 586 | US8481536, 404 | CHEMBL231218 | 4...)
Affinity DataIC50: 9.30nMAssay Description:Pdgfrβ (0.16 ug/well, Panvera/Invitrogen) 500 nM ATP and the PTK2 peptide (700 uM) were combined with compound and reaction buffer as noted abov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent

TargetEphrin type-B receptor 4(Human)
Targegen

US Patent
LigandPNGBDBM50198817(US8481536, 586 | US8481536, 404 | CHEMBL231218 | 4...)
Affinity DataIC50: 73.7nMT: 2°CAssay Description:EphB4 kinase activity was similarly measured, using the luciferase-based technique described above. 28.9 mU/well EphB4 (Upstate) was reacted with 1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent