BDBM50198826 4-(7-(2-chloro-6-hydroxyphenyl)-5-methylbenzo[e][1,2,4]triazin-3-ylamino)-N-(2-(pyrrolidin-1-yl)ethyl)benzenesulfonamide::CHEMBL231220::US8481536, 549

SMILES Cc1cc(cc2nnc(Nc3ccc(cc3)S(=O)(=O)NCCN3CCCC3)nc12)-c1c(O)cccc1Cl

InChI Key InChIKey=WQACVRFKZIYHIM-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50198826   

TargetTyrosine-protein kinase ABL1(Human)
Universita Degli Studi Di Palermo

Curated by ChEMBL
LigandPNGBDBM50198826(US8481536, 549 | CHEMBL231220 | 4-(7-(2-chloro-6-h...)
Affinity DataKi:  5nMAssay Description:Binding affinity to Abl (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Universita Degli Studi Di Palermo

Curated by ChEMBL
LigandPNGBDBM50198826(US8481536, 549 | CHEMBL231220 | 4-(7-(2-chloro-6-h...)
Affinity DataKi:  5nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

US Patent
LigandPNGBDBM50198826(US8481536, 549 | CHEMBL231220 | 4-(7-(2-chloro-6-h...)
Affinity DataIC50: 12.6nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

US Patent
LigandPNGBDBM50198826(US8481536, 549 | CHEMBL231220 | 4-(7-(2-chloro-6-h...)
Affinity DataIC50: 13nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Universita Degli Studi Di Palermo

Curated by ChEMBL
LigandPNGBDBM50198826(US8481536, 549 | CHEMBL231220 | 4-(7-(2-chloro-6-h...)
Affinity DataKi:  1.62E+3nMAssay Description:Binding affinity to Abl-T315I mutant (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed