BDBM50198973 CHEMBL396029::N-(1-(1H-indol-3-yl)propan-2-yl)-2,4,6-trichlorobenzenesulfonamide

SMILES CC(Cc1c[nH]c2ccccc12)NS(=O)(=O)c1c(Cl)cc(Cl)cc1Cl

InChI Key InChIKey=HSLFOYFJYRSLKF-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50198973   

TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50198973(N-(1-(1H-indol-3-yl)propan-2-yl)-2,4,6-trichlorobe...)
Affinity DataIC50: 64nMAssay Description:Displacement of TAMRA-labeled dexamethasone from glucocorticoid receptor (unknown origin) by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50198973(N-(1-(1H-indol-3-yl)propan-2-yl)-2,4,6-trichlorobe...)
Affinity DataIC50: 64nMAssay Description:Inhibition of human GRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50198973(N-(1-(1H-indol-3-yl)propan-2-yl)-2,4,6-trichlorobe...)
Affinity DataIC50: 130nMAssay Description:Binding affinity to mineralocorticoid receptor (unknown origin) by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50198973(N-(1-(1H-indol-3-yl)propan-2-yl)-2,4,6-trichlorobe...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human MRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50198973(N-(1-(1H-indol-3-yl)propan-2-yl)-2,4,6-trichlorobe...)
Affinity DataIC50: 570nMAssay Description:Inhibition of human PRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50198973(N-(1-(1H-indol-3-yl)propan-2-yl)-2,4,6-trichlorobe...)
Affinity DataIC50: 570nMAssay Description:Displacement of TAMRA-labeled mifepristone from progesterone receptor (unknown origin) by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50198973(N-(1-(1H-indol-3-yl)propan-2-yl)-2,4,6-trichlorobe...)
Affinity DataIC50: 2.00E+3nMAssay Description:Agonist activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed