BDBM50200594 1-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpentyl]-piperidin-4-yl}-3-(2-methylsulfanyl-ethyl)-1,3-dihydro-benzimidazol-2-one::CHEMBL393960

SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(CCSC)c2=O)C(C)C)c1

InChI Key InChIKey=RYRWIHMMTQHAQP-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50200594   

TargetNociceptin receptor(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50200594(1-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpenty...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50200594(1-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpenty...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]diprenorphine from human MOP receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50200594(1-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpenty...)
Affinity DataIC50: 42nMAssay Description:Agonist activity at human NOP receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50200594(1-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpenty...)
Affinity DataKi:  166nMAssay Description:Displacement of [3H]U-69593 from KOP receptor in guinea pig cortical tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50200594(1-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpenty...)
Affinity DataKi:  1.63E+3nMAssay Description:Displacement of [3H]naltrindole from human DOP receptor expressed in deltaC6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed