BDBM50200854 CHEMBL3895005

SMILES C[C@@H]1CN(Cc2ccccc2)c2cnccc2[C@H](C)N1C(=O)NCc1ccccc1

InChI Key InChIKey=QGMUDAKKGSLGLA-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50200854   

TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50200854(CHEMBL3895005)
Affinity DataIC50: 15nMAssay Description:Channel blocking activity at recombinant human CaV 3.3 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2018
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50200854(CHEMBL3895005)
Affinity DataIC50: 23nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50200854(CHEMBL3895005)
Affinity DataIC50: 25nMAssay Description:Channel blocking activity at recombinant human CaV 3.3 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50200854(CHEMBL3895005)
Affinity DataIC50: 25nMAssay Description:Channel blocking activity at recombinant human CaV 3.3 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50200854(CHEMBL3895005)
Affinity DataIC50: 55nMAssay Description:Inhibition of Cav3.3 subunit 1alpha-l(unknown origin) stably transfected in HEK293 cells measured by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50200854(CHEMBL3895005)
Affinity DataIC50: 138nMAssay Description:Channel blocking activity at recombinant human CaV 3.1 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50200854(CHEMBL3895005)
Affinity DataIC50: 142nMAssay Description:Channel blocking activity at recombinant human CaV 3.1 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50200854(CHEMBL3895005)
Affinity DataIC50: 230nMAssay Description:Channel blocking activity at recombinant human CaV 3.2 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50200854(CHEMBL3895005)
Affinity DataIC50: 236nMAssay Description:Channel blocking activity at recombinant human CaV 3.2 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50200854(CHEMBL3895005)
Affinity DataIC50: 236nMAssay Description:Channel blocking activity at recombinant human CaV 3.2 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50200854(CHEMBL3895005)
Affinity DataIC50: 260nMAssay Description:Channel blocking activity at recombinant human CaV 3.1 channel expressed in HEK293 cells assessed as inhibition of Ca2+ flux preincubated for 3 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2018
Entry Details Article
PubMed