BDBM50202672 CHEMBL3900937::US10730889, Example 15::US11485745, Example 15

SMILES CC(C)(C)OC(=O)N1CCC2(CC2CNC(=O)c2cnc3[nH]ncc3c2)CC1

InChI Key InChIKey=MQIGINOTGYCQHA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50202672   

TargetNicotinamide phosphoribosyltransferase(Human)
Valo Health

US Patent
LigandChemical structure of BindingDB Monomer ID 50202672BDBM50202672(CHEMBL3900937 | US10730889, Example 15 | US1148574...)
Affinity DataIC50: 49.9nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 17.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Valo Health

US Patent
LigandChemical structure of BindingDB Monomer ID 50202672BDBM50202672(CHEMBL3900937 | US10730889, Example 15 | US1148574...)
Affinity DataIC50: 2.00E+3nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 17.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Valo Health

US Patent
LigandChemical structure of BindingDB Monomer ID 50202672BDBM50202672(CHEMBL3900937 | US10730889, Example 15 | US1148574...)
Affinity DataIC50: 2.00E+3nMAssay Description:NAMPT Protein Purification. Recombinant His-tagged NAMPT was produced in E. coli cells, purified over a Ni column, and further purified over a size-e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2021
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Valo Health

US Patent
LigandChemical structure of BindingDB Monomer ID 50202672BDBM50202672(CHEMBL3900937 | US10730889, Example 15 | US1148574...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human full length C-terminal His6-tagged NAMPT expressed in Escherichia coli Rosetta (DE3) cells using nicotinamide as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2018
Entry Details Article
PubMed