BDBM50203931 (S)-N-(2-methyl-3-(trifluoromethyl)benzyl)-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amine::CHEMBL391143

SMILES Cc1c(CN([C@H]2CCNC2)C2CCOCC2)cccc1C(F)(F)F

InChI Key InChIKey=OVZCYWBNBLGMMB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50203931   

TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203931((S)-N-(2-methyl-3-(trifluoromethyl)benzyl)-N-(tetr...)
Affinity DataIC50: 13nMAssay Description:Inhibition of [3H]5-HT from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203931((S)-N-(2-methyl-3-(trifluoromethyl)benzyl)-N-(tetr...)
Affinity DataIC50: 20nMAssay Description:Inhibition of [3H]NA from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203931((S)-N-(2-methyl-3-(trifluoromethyl)benzyl)-N-(tetr...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203931((S)-N-(2-methyl-3-(trifluoromethyl)benzyl)-N-(tetr...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of [3H]DA from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203931((S)-N-(2-methyl-3-(trifluoromethyl)benzyl)-N-(tetr...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed