BDBM50203943 CHEMBL245687::biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-(tetrahydro-pyran-4-yl)-amine

SMILES C(N([C@H]1CCNC1)C1CCOCC1)c1ccccc1-c1ccccc1

InChI Key InChIKey=KAVHHDMCLXFYPS-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50203943   

LigandPNGBDBM50203943(biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-(tetrahydr...)
Affinity DataIC50: 12nMAssay Description:Inhibition of [3H]NA from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203943(biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-(tetrahydr...)
Affinity DataIC50: 12nMAssay Description:Inhibition of [3H]NA uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203943(biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-(tetrahydr...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203943(biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-(tetrahydr...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203943(biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-(tetrahydr...)
Affinity DataIC50: 400nMAssay Description:Inhibition of [3H]5-HT from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203943(biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-(tetrahydr...)
Affinity DataIC50: 400nMAssay Description:Inhibition of [3H]5HT uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203943(biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-(tetrahydr...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of [3H]DA from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203943(biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-(tetrahydr...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed