BDBM50204125 (S)-N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-6-methoxy-5-((morpholin-2-ylmethoxy)methyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine::CHEMBL395883

SMILES COc1cn2ncnc(Nc3ccc4n(Cc5cccc(F)c5)ncc4c3)c2c1COC[C@@H]1CNCCO1

InChI Key InChIKey=RKYBUDCAJWXFQO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50204125   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50204125((S)-N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-6-metho...)
Affinity DataIC50: 250nMAssay Description:Inhibition of human recombinant HER2 expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50204125((S)-N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-6-metho...)
Affinity DataIC50: 250nMAssay Description:Inhibition of human recombinant cytoplasmic HER2 kinase expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50204125((S)-N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-6-metho...)
Affinity DataIC50: 430nMAssay Description:Inhibition of human recombinant EGFR expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50204125((S)-N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-6-metho...)
Affinity DataIC50: 430nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed