BDBM50204587 (S)-6-(4-(2-(dimethylamino)ethoxy)phenyl)-5-phenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine::CHEMBL247479

SMILES CN(C)CCOc1ccc(cc1)-c1oc2ncnc(NC[C@@H]3CCCO3)c2c1-c1ccccc1

InChI Key InChIKey=XNSZHQUDPHATEN-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50204587   

TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50204587((S)-6-(4-(2-(dimethylamino)ethoxy)phenyl)-5-phenyl...)
Affinity DataKi:  5nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50204587((S)-6-(4-(2-(dimethylamino)ethoxy)phenyl)-5-phenyl...)
Affinity DataIC50: 6nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50204587((S)-6-(4-(2-(dimethylamino)ethoxy)phenyl)-5-phenyl...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human LCK using peptide poly[Glu:Tyr] (4:1) substrate by 33P Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50204587((S)-6-(4-(2-(dimethylamino)ethoxy)phenyl)-5-phenyl...)
Affinity DataIC50: 11nMAssay Description:Inhibition of ACK1 kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50204587((S)-6-(4-(2-(dimethylamino)ethoxy)phenyl)-5-phenyl...)
Affinity DataIC50: 11nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Mouse)
Amgen

Curated by ChEMBL
LigandPNGBDBM50204587((S)-6-(4-(2-(dimethylamino)ethoxy)phenyl)-5-phenyl...)
Affinity DataIC50: 30nMAssay Description:Inhibition of ACK1 in mouse C8 cells assessed as decrease in cell viability after 20 to 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed