BDBM50204595 CHEMBL3889667::US10285989, Example 94
SMILES CN(C)c1nc(cc(=O)[nH]1)C(=O)NC1(CC1)c1ccc(c(F)c1)C(F)(F)F
InChI Key InChIKey=HHNSDGKEUZAJEJ-UHFFFAOYSA-N
Data 5 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50204595
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Therachem Research Medilab (India)
Curated by ChEMBL
Therachem Research Medilab (India)
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:Inhibition of rhesus monkey PDE2A3 expressed in AD293 cells using FAM-labeled cAMP as substrate after 60 mins in presence of cGMP by florescence pola...More data for this Ligand-Target Pair
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Therachem Research Medilab (India)
Curated by ChEMBL
Therachem Research Medilab (India)
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataKi: 0.900nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataKi: 0.960nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Therachem Research Medilab (India)
Curated by ChEMBL
Therachem Research Medilab (India)
Curated by ChEMBL
Affinity DataKi: 1.20nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair