BDBM50204595 CHEMBL3889667::US10285989, Example 94

SMILES CN(C)c1nc(cc(=O)[nH]1)C(=O)NC1(CC1)c1ccc(c(F)c1)C(F)(F)F

InChI Key InChIKey=HHNSDGKEUZAJEJ-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50204595   

TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50204595(CHEMBL3889667 | US10285989, Example 94)
Affinity DataKi:  0.800nMAssay Description:Inhibition of rhesus monkey PDE2A3 expressed in AD293 cells using FAM-labeled cAMP as substrate after 60 mins in presence of cGMP by florescence pola...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50204595(CHEMBL3889667 | US10285989, Example 94)
Affinity DataKi:  0.800nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50204595(CHEMBL3889667 | US10285989, Example 94)
Affinity DataKi:  0.900nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50204595(CHEMBL3889667 | US10285989, Example 94)
Affinity DataKi:  0.960nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50204595(CHEMBL3889667 | US10285989, Example 94)
Affinity DataKi:  1.20nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In DepthDetails US Patent