BDBM50204779 8-(8-chloro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL393781

SMILES Clc1cccc2CCCC(N3CCC4(CC3)N(CNC4=O)c3ccccc3)c12

InChI Key InChIKey=LUTRYIHVLIPQAF-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50204779   

TargetNociceptin receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50204779(8-(8-chloro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50204779(8-(8-chloro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50204779(8-(8-chloro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Affinity DataKi:  143nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50204779(8-(8-chloro-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Affinity DataKi:  1.38E+3nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed