BDBM50205686 CHEMBL230607::N1-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylethyl)-N1-methyl-N3-(thiazol-2-yl)malonamide

SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)CC(=O)Nc1nccs1

InChI Key InChIKey=OTVDTTAKAMCEFZ-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50205686   

TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50205686(N1-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenyle...)
Affinity DataKi:  0.530nMAssay Description:Agonist activity at human kappa opioid receptor by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50205686(N1-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenyle...)
Affinity DataIC50: 700nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed