BDBM50205852 CHEMBL3976578::US10280165, Example 38

SMILES Cc1cc([C@@H]2C[C@H]2C#N)n2c(c1)nc(Cn1nc(cc1Cl)C(F)(F)F)cc2=O

InChI Key InChIKey=XSISCWOKUQLCCR-CMPLNLGQSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50205852   

TargetGlutamate receptor 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50205852(CHEMBL3976578 | US10280165, Example 38)
Affinity DataEC50:  210nMAssay Description:Positive allosteric modulation of human GluA2 receptor flop isoform assessed as increase in glutamate-induced calcium flux measured at time interval ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50205852(CHEMBL3976578 | US10280165, Example 38)
Affinity DataEC50:  39nMAssay Description:TBDMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutamate receptor 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50205852(CHEMBL3976578 | US10280165, Example 38)
Affinity DataEC50:  210nMAssay Description:Positive allosteric modulation of human GluA2 receptor flop isoform assessed as increase in glutamate-induced calcium flux measured at time interval ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50205852(CHEMBL3976578 | US10280165, Example 38)
Affinity DataEC50:  39nMAssay Description:Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed