BDBM50205853 CHEMBL3968067::US10280165, Example 52

SMILES COc1ccc2nc(Cn3nc(cc3Cl)C(F)(F)F)cc(=O)n2c1[C@@H]1C[C@H]1C#N

InChI Key InChIKey=CANODGNUGMXXDV-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50205853   

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Genentech

US Patent
LigandPNGBDBM50205853(CHEMBL3968067 | US10280165, Example 52)
Affinity DataEC50:  79nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Genentech

US Patent
LigandPNGBDBM50205853(CHEMBL3968067 | US10280165, Example 52)
Affinity DataEC50:  80nMAssay Description:Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed