BDBM50207854 CHEMBL246356::N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yloxy)phenyl)-3-(1,1,2,2-tetrafluoroethoxy)benzamide

SMILES CNc1ncnc(n1)-c1cccnc1Oc1cc(NC(=O)c2cccc(OC(F)(F)C(F)F)c2)ccc1C

InChI Key InChIKey=GHRNBCMJJKMYNR-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50207854   

TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 16nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 33nMAssay Description:Inhibition of Tie2 autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 47nMAssay Description:Inhibition of p38-alpha by radioactive filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 146nMAssay Description:Inhibition of Lck by radioactive filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 194nMAssay Description:Inhibition of p38-alpha in THP1 cells assessed as TNFalpha levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibition of Jak2 by radioactive filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of Src by radioactive filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of KDR autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 1.78E+4nMAssay Description:Inhibition of cKit by radioactive filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of Zap70 by radioactive filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of IGFR1 by radioactive filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of EGFR by radioactive filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of cMet by radioactive filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of BTK by radioactive filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of JNK3 by radioactive filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed