BDBM50208911 CHEMBL3884319

SMILES CC1(C)C(=O)N([C@H]2CCc3c2cccc3O)c2nc(Nc3ccccc3)ncc12

InChI Key InChIKey=XLFNLJYGUOLEJS-UHFFFAOYSA-N

Data  100 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 100 hits for monomerid = 50208911   

LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of full length human MARK3 using biotin labeled peptide substrate by HTRF based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant full length His-tagged NUAK1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant His-tagged FLT3 cytoplasmic domain (564 to 958 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 21nMAssay Description:Inhibition of human MARK4 expressed in HEK293T cells coexpressing tau protein assessed as reduction in tau phosphorylation at Ser262 residues by Alph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 76nMAssay Description:Inhibition of human recombinant His-tagged KIT cytoplasmic domain (544 to 976 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 98nMAssay Description:Inhibition of human recombinant full length N-terminal GST/N-terminal His-tagged AMPK alpha1/beta1/gamma1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 136nMAssay Description:Inhibition of human recombinant full length His-tagged PDK1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 157nMAssay Description:Inhibition of human recombinant His-tagged NTRK3 cytoplasmic domain (510 to 825 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 163nMAssay Description:Inhibition of human recombinant full length His-tagged AURKB expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 167nMAssay Description:Inhibition of human full length wild type DYKDDDDK-tagged LRRK2 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 206nMAssay Description:Inhibition of human recombinant full length N-terminal GST/N-terminal His-tagged AMPK alpha2/beta1/gamma1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 494nMAssay Description:Inhibition of human recombinant His-tagged NTRK1 cytoplasmic domain (441 to 796 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 591nMAssay Description:Inhibition of human recombinant His-tagged FGFR2 cytoplasmic domain (403 to 822 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 605nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 658nMAssay Description:Inhibition of human recombinant full length GST/His-tagged CDK5/P25 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 668nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged SRC cytoplasmic domain expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 692nMAssay Description:Inhibition of human recombinant full length His-tagged RPS6KA3 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 793nMAssay Description:Inhibition of human recombinant full length His-tagged CDK7/cyclin H/MNAT1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 818nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged LCK cytoplasmic domain expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 1.01E+3nMAssay Description:Inhibition of human recombinant GST-tagged CLK2 catalytic domain (137 to 498 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of human recombinant GST-tagged TEK cytoplasmic domain (817 to 1101 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of human recombinant full length His-tagged ABL1 cytoplasmic domain expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of human recombinant GST-tagged JAK2 cytoplasmic domain (809 to 1153 +9 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of human recombinant GST-tagged INSR cytoplasmic domain (1011 to 1382 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of human recombinant N-terminal His-tagged MET cytoplasmic domain (956 to 1390 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of human recombinant GST-tagged MAP3K8 catalytic domain (30 to 397 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of human recombinant full length His-tagged BMX cytoplasmic domain expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of human recombinant His-tagged KDR cytoplasmic domain (789 to 1356 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of human recombinant full length His-tagged CDK9/cyclin T1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 1.83E+3nMAssay Description:Inhibition of human recombinant full length GST-tagged MAPK1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 1.86E+3nMAssay Description:Inhibition of human full length N-terminal GST-tagged HCK cytoplasmic domain expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 1.88E+3nMAssay Description:Inhibition of human recombinant full length His-tagged BTK cytoplasmic domain expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 2.04E+3nMAssay Description:Inhibition of human recombinant full length GST-tagged BRAF expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetEphrin type-A receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 2.09E+3nMAssay Description:Inhibition of human recombinant His-tagged EPHA3 cytoplasmic domain (569 to 976 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 2.14E+3nMAssay Description:Inhibition of human recombinant C-terminal His-tagged IGF1R cytoplasmic domain (960 to 1397 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetEphrin type-B receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 2.16E+3nMAssay Description:Inhibition of human recombinant GST-tagged EPHB2 cytoplasmic domain (616 to 884 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 2.17E+3nMAssay Description:Inhibition of human recombinant full length His-tagged CHEK2 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 26(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 2.22E+3nMAssay Description:Inhibition of human recombinant full length GST-tagged MST4 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 2.99E+3nMAssay Description:Inhibition of human recombinant full length His-tagged GSK3B expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 3.12E+3nMAssay Description:Inhibition of human recombinant full length His-tagged STK22D expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of human recombinant GST-tagged JAK3 cytoplasmic domain (781 to 1124 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 3.31E+3nMAssay Description:Inhibition of human full length N-terminal GST-tagged GSK3A expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetActivin receptor type-1B(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant GST-tagged ALK4 catalytic domain (150 to 505 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant GST-tagged PASK catalytic domain (879 to 1323 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length His-tagged MAP2K6 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length GST-tagged IKKepsilon expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length GST-tagged DYRK1A expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length His-tagged MAPK8 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant His-tagged PRKACA catalytic domain (1 to 351 residues) expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
Displayed 1 to 50 (of 100 total ) | Next | Last >>