BDBM50209655 CHEMBL3885053

SMILES CN1CCN(CC1)c1ccc(Nc2ncc3ccn(-c4ccccc4NC(=O)C=C)c3n2)cc1

InChI Key InChIKey=NKRHFMHDJJWWDW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50209655   

TargetMitogen-activated protein kinase kinase kinase 7(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50209655(CHEMBL3885053)
Affinity DataIC50: 3.01E+3nMAssay Description:Inhibition of TAK1 (unknown origin) by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50209655(CHEMBL3885053)
Affinity DataIC50: 3.01E+3nMAssay Description:Inhibition of full length recombinant human GST-tagged TAK1 expressed in baculovirus expression system after 1 hr by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2018
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50209655(CHEMBL3885053)
Affinity DataIC50: 6.81E+3nMAssay Description:Inhibition of full length recombinant human His-tagged MEK1 expressed in baculovirus expression system after 1 hr by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2018
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50209655(CHEMBL3885053)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human GST-tagged ERK2 expressed in Escherichia coli using Ser/Thr 03 as substrate after 1 hr by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2018
Entry Details Article
PubMed