BDBM50210072 CHEMBL3884830

SMILES Cc1nc(N)ccc1CNC(=O)c1cnn(Cc2ccc(Cn3cccn3)cc2)c1

InChI Key InChIKey=WWJLNLGOEPGLIB-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50210072   

TargetPlasma kallikrein(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50210072(CHEMBL3884830)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human plasma kallikrein using D-Pro-Phe-Arg-pNA as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50210072(CHEMBL3884830)
Affinity DataIC50: 1.06E+5nMAssay Description:Inhibition of factor 11a (unknown origin) using S-2366 as substrate incubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50210072(CHEMBL3884830)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of factor 12a (unknown origin) using D-Pro-Phe-Arg-pNA as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50210072(CHEMBL3884830)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of factor 10a (unknown origin) using N-Z-D-Arg-Gly-Arg-pNA as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetProthrombin(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50210072(CHEMBL3884830)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of alpha-thrombin (unknown origin) using D-Phe-Pip-Arg-pNA as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50210072(CHEMBL3884830)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of tPA (unknown origin) using Methylsulfonyl-D-Phe-Gly-Arg-pNA as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetPlasminogen(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50210072(CHEMBL3884830)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of Lys-plasmin (unknown origin) using Tosyl-Gly-Pro-Lys-4-nitranilide as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed