BDBM50210983 (R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-bromophenylamino)-4-(methylamino)cyclobut-3-ene-1,2-dione::CHEMBL232253

SMILES CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O

InChI Key InChIKey=NOFUPGBMLMZXFI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50210983   

TargetC-C chemokine receptor type 1(Human)
Tanabe Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50210983((R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Tanabe Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50210983((R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: 25nMAssay Description:Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Tanabe Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50210983((R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: 25nMAssay Description:Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed