BDBM50213102 (S,S)-(+)-1-p-methoxyphenyl-2-(beta-3',5'-dihydroxyphenyl-beta-oxy)ethylamino-propane::CHEMBL228417::US10617654, Compound (S,S)-2::US9249163, 35

SMILES COc1ccc(C[C@H](C)NC[C@@H](O)c2cc(O)cc(O)c2)cc1

InChI Key InChIKey=WHAUNCTVVNUUIP-UHFFFAOYSA-N

Data  6 KI  1 IC50  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50213102   

TargetBeta-2 adrenergic receptor(Human)
Medical University of Lublin

Curated by ChEMBL
LigandPNGBDBM50213102((S,S)-(+)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataEC50:  33nMAssay Description:Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Medical University of Lublin

Curated by ChEMBL
LigandPNGBDBM50213102((S,S)-(+)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataIC50: 337nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
Medical University of Lublin

Curated by ChEMBL
LigandPNGBDBM50213102((S,S)-(+)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataKi:  2.87E+3nMAssay Description:Displacement of [3H]-(R,R')-methoxyfenoterol from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Medical University of Lublin

Curated by ChEMBL
LigandPNGBDBM50213102((S,S)-(+)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataKi:  2.87E+3nMAssay Description:Displacement of [3H]-(R,R')-methoxyfenoterol from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Medical University of Lublin

Curated by ChEMBL
LigandPNGBDBM50213102((S,S)-(+)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataKi:  1.58E+4nMAssay Description:Displacement of [3H]CGP12177 from human beta-2 adrenergic receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Medical University of Lublin

Curated by ChEMBL
LigandPNGBDBM50213102((S,S)-(+)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataKd:  1.58E+4nMAssay Description:HEK 293 cells stability transfected with cDNA encoding human β2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetBeta-1 adrenergic receptor(Rat)
Medical University of Lublin

Curated by ChEMBL
LigandPNGBDBM50213102((S,S)-(+)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]CGP-12177 from beta-1 adrenergic receptor in Sprague-Dawley rat cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Medical University of Lublin

Curated by ChEMBL
LigandPNGBDBM50213102((S,S)-(+)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataKi:  1.59E+7nMAssay Description:HEK 293 cells stability transfected with cDNA encoding human β2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetBeta-1 adrenergic receptor(Mouse)
Department Of Health and Human Services

US Patent
LigandPNGBDBM50213102((S,S)-(+)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataKi: >1.00E+8nMAssay Description:β1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent