BDBM50214099 CHEMBL400569::N-((5-(3-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)methyl)ethanamine

SMILES CCNCc1cncc(c1)-c1cnc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCN(C)CC3)c2c1

InChI Key InChIKey=VBYCLUNCQJLFHE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50214099   

TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50214099(CHEMBL400569 | N-((5-(3-(5-(4-methylpiperazin-1-yl...)
Affinity DataIC50:  1.07E+3nMAssay Description:Inhibition of HER2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50214099(CHEMBL400569 | N-((5-(3-(5-(4-methylpiperazin-1-yl...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50214099(CHEMBL400569 | N-((5-(3-(5-(4-methylpiperazin-1-yl...)
Affinity DataIC50:  140nMAssay Description:Inhibition of RET kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50214099(CHEMBL400569 | N-((5-(3-(5-(4-methylpiperazin-1-yl...)
Affinity DataIC50:  140nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50214099(CHEMBL400569 | N-((5-(3-(5-(4-methylpiperazin-1-yl...)
Affinity DataIC50:  25nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed