BDBM50216179 CHEMBL395084::N-[(1S)-1-benzyl-2-hydroxyethyl]-2-[(isopropylsulfonyl)(methyl)amino]-6-({[(1S,2S)-2-methylcyclopropyl]methyl}amino)isonicotinamide

SMILES CC(C)S(=O)(=O)N(C)c1cc(cc(NC[C@H]2C[C@@H]2C)n1)C(=O)N[C@H](CO)Cc1cc(F)cc(F)c1

InChI Key InChIKey=AURIBKKPUXEPLA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50216179   

TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50216179(N-[(1S)-1-benzyl-2-hydroxyethyl]-2-[(isopropylsulf...)
Affinity DataIC50: 14nMAssay Description:Inhibition of BACE1 by ECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50216179(N-[(1S)-1-benzyl-2-hydroxyethyl]-2-[(isopropylsulf...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of BACE1 assessed as effect on soluble APPbeta N-terminal fragment secretion in HEK293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed