BDBM50216474 5-(3-chlorobenzyl)-6-(4-phenylpiperidin-1-yl)pyrimidine-2,4(1H,3H)-dione::CHEMBL230989

SMILES Clc1cccc(Cc2c([nH]c(=O)[nH]c2=O)N2CCC(CC2)c2ccccc2)c1

InChI Key InChIKey=IRZVQRHERMOSEM-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50216474   

TargetGlucocorticoid receptor(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50216474(5-(3-chlorobenzyl)-6-(4-phenylpiperidin-1-yl)pyrim...)
Affinity DataKi:  9.10nMAssay Description:Displacement of [3H]dexamethasone from human recombinant GRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50216474(5-(3-chlorobenzyl)-6-(4-phenylpiperidin-1-yl)pyrim...)
Affinity DataKi:  96nMAssay Description:Antagonist activity at human GRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50216474(5-(3-chlorobenzyl)-6-(4-phenylpiperidin-1-yl)pyrim...)
Affinity DataKi:  585nMAssay Description:Displacement of [3H]aldosterone from mineralocorticoid receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50216474(5-(3-chlorobenzyl)-6-(4-phenylpiperidin-1-yl)pyrim...)
Affinity DataKi:  7.05E+3nMAssay Description:Displacement of [3H]progesterone from progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed