BDBM50218712 3-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5Hdibenzo[b,e][1,4]diazepin-8-yl]-N-(4-morpholin-4-ylphenyl)propanamide::CHEMBL243499

SMILES COc1cc(ccc1N)-c1ccc2c(Nc3ccc(CCC(=O)Nc4ccc(cc4)N4CCOCC4)cc3NC2=O)c1

InChI Key InChIKey=PGZHCVLSYNCIRY-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50218712   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50218712(3-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydr...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50218712(3-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydr...)
Affinity DataEC50: >5.93E+4nMAssay Description:Antiproliferative activity against HeLa cells by MTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50218712(3-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydr...)
Affinity DataEC50: >1.00E+4nMAssay Description:Cell cycle arrest in HeLa cells assessed as accumulation at G2/M phase by FACS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed