BDBM50219107 CHEMBL394541::N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)-trans-but-2-enyl)-4-pyridin-2-ylbenzamide::US8748608, 14

SMILES COc1ccccc1N1CCN(C\C=C\CNC(=O)c2ccc(cc2)-c2ccccn2)CC1

InChI Key InChIKey=UCNUZCBZAAKMDU-VOTSOKGWSA-N

Data  6 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50219107   

TargetD(3) dopamine receptor(Human)
The United States of America As Represented By The Secretary of The Department of Health and Human Services

US Patent
LigandPNGBDBM50219107(CHEMBL394541 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  2.90nM IC50:  42.6nMAssay Description:Methods for performing in vitro dopamine receptor binding studies are described in Huang et al. J. Med. Chem. 44:1815-1826 (2001) and Luedtke et al. ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetD(3) dopamine receptor(Human)
The United States of America As Represented By The Secretary of The Department of Health and Human Services

US Patent
LigandPNGBDBM50219107(CHEMBL394541 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [125I]IABN from human dopamine D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219107(CHEMBL394541 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  21.7nMAssay Description:Binding affinity to human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219107(CHEMBL394541 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  69nMAssay Description:Displacement of [125I]IABN from human dopamine D2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219107(CHEMBL394541 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  75.3nMAssay Description:Binding affinity to human 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219107(CHEMBL394541 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  256nMAssay Description:Binding affinity to human 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
The United States of America As Represented By The Secretary of The Department of Health and Human Services

US Patent
LigandPNGBDBM50219107(CHEMBL394541 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataIC50:  42.6nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219107(CHEMBL394541 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataIC50:  175nMT: 37°CAssay Description:To measure D2 and D3 stimulation of mitogenesis (agonist assay) or D2 and D3 inhibition of quinpirole stimulation of mitogenesis (antagonist assay), ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219107(CHEMBL394541 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataIC50:  175nMAssay Description:Antagonist activity at human dopamine D2 receptor expressed in HEK293 cells by mitogenesis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed