BDBM50219113 CHEMBL244989::N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)-trans-but-2-enyl)-9H-fluorene-2-carboxamide::US8748608, 15

SMILES COc1ccccc1N1CCN(C\C=C\CNC(=O)c2ccc-3c(Cc4ccccc-34)c2)CC1

InChI Key InChIKey=UUYDEYACQFNFMI-VOTSOKGWSA-N

Data  6 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50219113   

TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219113(CHEMBL244989 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [125I]IABN from human dopamine D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219113(CHEMBL244989 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  12nM IC50:  18.9nMAssay Description:Methods for performing in vitro dopamine receptor binding studies are described in Huang et al. J. Med. Chem. 44:1815-1826 (2001) and Luedtke et al. ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219113(CHEMBL244989 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  48.4nMAssay Description:Displacement of [125I]IABN from human dopamine D2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219113(CHEMBL244989 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  65.7nMAssay Description:Binding affinity to human 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219113(CHEMBL244989 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  71.8nMAssay Description:Binding affinity to human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219113(CHEMBL244989 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  176nMAssay Description:Binding affinity to human 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219113(CHEMBL244989 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataIC50:  179nMT: 37°CAssay Description:To measure D2 and D3 stimulation of mitogenesis (agonist assay) or D2 and D3 inhibition of quinpirole stimulation of mitogenesis (antagonist assay), ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219113(CHEMBL244989 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataIC50:  18.9nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219113(CHEMBL244989 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataIC50:  179nMAssay Description:Antagonist activity at human dopamine D2 receptor expressed in HEK293 cells by mitogenesis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed