BDBM50219919 6-(4-((phenethylamino)methyl)phenoxy)nicotinamide::CHEMBL238361

SMILES NC(=O)c1ccc(Oc2ccc(CNCCc3ccccc3)cc2)nc1

InChI Key InChIKey=XPIWSPZHJZLUGI-UHFFFAOYSA-N

Data  9 KI  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50219919   

TargetMu-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50219919BDBM50219919(6-(4-((phenethylamino)methyl)phenoxy)nicotinamide ...)
Affinity DataKi:  0.0700nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50219919BDBM50219919(6-(4-((phenethylamino)methyl)phenoxy)nicotinamide ...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cells in presence of high sodium by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50219919BDBM50219919(6-(4-((phenethylamino)methyl)phenoxy)nicotinamide ...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]diprenorphine from cloned human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50219919BDBM50219919(6-(4-((phenethylamino)methyl)phenoxy)nicotinamide ...)
Affinity DataKi:  0.970nMAssay Description:Antagonist activity at human delta opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50219919BDBM50219919(6-(4-((phenethylamino)methyl)phenoxy)nicotinamide ...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]bremazocine from human delta opioid receptor expressed in CHO cells in presence of high sodium by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50219919BDBM50219919(6-(4-((phenethylamino)methyl)phenoxy)nicotinamide ...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]bremazocine from cloned human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50219919BDBM50219919(6-(4-((phenethylamino)methyl)phenoxy)nicotinamide ...)
Affinity DataKi:  1.20nMAssay Description:Antagonist activity at human kappa opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50219919BDBM50219919(6-(4-((phenethylamino)methyl)phenoxy)nicotinamide ...)
Affinity DataKi:  8.40nMAssay Description:Displacement of [3H]diprenorphine from cloned human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50219919BDBM50219919(6-(4-((phenethylamino)methyl)phenoxy)nicotinamide ...)
Affinity DataKi:  8.40nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cells in presence of high sodium by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
University of Kentucky

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50219919BDBM50219919(6-(4-((phenethylamino)methyl)phenoxy)nicotinamide ...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of Norepinephrine transporter (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Human)
University of Kentucky

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50219919BDBM50219919(6-(4-((phenethylamino)methyl)phenoxy)nicotinamide ...)
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of Dopamine transporter (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
University of Kentucky

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50219919BDBM50219919(6-(4-((phenethylamino)methyl)phenoxy)nicotinamide ...)
Affinity DataIC50: 3.74E+3nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetAlpha-1A adrenergic receptor(Human)
University of Kentucky

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50219919BDBM50219919(6-(4-((phenethylamino)methyl)phenoxy)nicotinamide ...)
Affinity DataIC50: 2.16E+5nMAssay Description:Antagonist activity at alpha1A adrenoreceptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
University of Kentucky

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50219919BDBM50219919(6-(4-((phenethylamino)methyl)phenoxy)nicotinamide ...)
Affinity DataEC50:  2.56E+5nMAssay Description:Antagonist activity at D2S receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed