BDBM50220278 1-((2R,6S)-1-(4-chlorophenylsulfonyl)-6-(2,2,2-trifluoroethyl)piperidin-2-yl)cyclopropyl 4-(2-hydroxyethyl)piperazine-1-carboxylate::CHEMBL240071

SMILES OCCN1CCN(CC1)C(=O)OC1(CC1)[C@H]1CCC[C@@H](CC(F)(F)F)N1S(=O)(=O)c1ccc(Cl)cc1

InChI Key InChIKey=OEMOPPHKWFSUEF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50220278   

TargetAmyloid-beta precursor protein(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50220278(1-((2R,6S)-1-(4-chlorophenylsulfonyl)-6-(2,2,2-tri...)
Affinity DataIC50: 14nMAssay Description:Inhibition of gamma-secretase assessed as reduction of membrane A-beta-40 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed