BDBM50220289 (R)-1-((2R,6R)-1-(4-chlorophenylsulfonyl)-6-propylpiperidin-2-yl)cyclopropyl 3-hydroxypyrrolidine-1-carboxylate::CHEMBL240285

SMILES CCC[C@@H]1CCC[C@@H](N1S(=O)(=O)c1ccc(Cl)cc1)C1(CC1)OC(=O)N1CC[C@@H](O)C1

InChI Key InChIKey=VCSMPFGNSZFRRW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50220289   

TargetAmyloid-beta precursor protein(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50220289((R)-1-((2R,6R)-1-(4-chlorophenylsulfonyl)-6-propyl...)
Affinity DataIC50: 47nMAssay Description:Inhibition of gamma-secretase assessed as reduction of membrane A-beta-40 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed