BDBM50221557 (4-(7-(2-chloro-5-hydroxyphenyl)-5-methylbenzo[e][1,2,4]triazin-3-ylamino)phenyl)(4-methylpiperazin-1-yl)methanone::CHEMBL399246::US8481536, 504

SMILES CN1CCN(CC1)C(=O)c1ccc(Nc2nnc3cc(cc(C)c3n2)-c2cc(O)ccc2Cl)cc1

InChI Key InChIKey=DKNHELJFXSXKQW-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50221557   

TargetTyrosine-protein kinase ABL1(Human)
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Curated by ChEMBL
LigandPNGBDBM50221557(US8481536, 504 | CHEMBL399246 | (4-(7-(2-chloro-5-...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
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US Patent
LigandPNGBDBM50221557(US8481536, 504 | CHEMBL399246 | (4-(7-(2-chloro-5-...)
Affinity DataIC50: 2.90nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent